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Dental problems if low Vitamin D (Hill's, Global Rec.) - Grant June 2023

Periodontal Disease and Other Adverse Health Outcomes Share Risk Factors, including Dietary Factors and Vitamin D Status

Nutrients . 2023 Jun 17;15(12):2787. doi: 10.3390/nu15122787.
William B Grant 1, Barbara M van Amerongen 2, Barbara J Boucher 3

Chart: More D less PD

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For nearly a century, researchers have associated periodontal disease (PD) with risks of other adverse health outcomes such as cardiovascular disease, diabetes mellitus, and respiratory diseases, as well as adverse pregnancy outcomes. Those findings have led to the hypothesis that PD causes those adverse health outcomes either by increasing systemic inflammation or by the action of periodontopathic bacteria. However, experiments largely failed to support that hypothesis. Instead, the association is casual, not causal, and is due to shared underlying modifiable risk factors, including smoking, diet, obesity, low levels of physical activity, and low vitamin D status. Diabetes mellitus is also considered a risk factor for PD, whereas red and processed meat are the most important dietary risk factors for diabetes. Because PD generally develops before other adverse health outcomes, a diagnosis of PD can alert patients that they could reduce the risk of adverse health outcomes with lifestyle changes. In addition, type 2 diabetes mellitus can often be reversed rapidly by adopting an anti-inflammatory, nonhyperinsulinemic diet that emphasizes healthful, whole plant-based foods. This review describes the evidence that proinflammatory and prohyperinsulinemia diets and low vitamin D status are important risk factors for PD and other adverse health outcomes. We also make recommendations regarding dietary patterns, food groups, and serum 25-hydroxyvitamin D concentrations. Oral health professionals should routinely inform patients with PD that they could reduce their risk of severe PD as well as the risks of many other adverse health outcomes by making appropriate lifestyle changes.

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Hills Criterion
CriterionMeaning
Strength of associationOR or RR between 1 and 2 is considered weak, whereas >2.0 is considered strong.
ConsistencySimilar findings in different situations.
SpecificityA factor influences specifically a particular outcome or population.
TemporalityThe causal agent should precede the incidence of an expected outcome.
Biological gradientA monotonically changing dose-response relationship.
PlausibilityMechanisms exist to explain the effect.
CoherenceThe interpretation should not seriously conflict with generally known facts of the natural history and biology of the disease.
ExperimentRCTs are generally the strongest type of evidence. They should be for disease outcomes, not merely biological parameters related to diseases. In the absence of RCTs, prospective studies may be used.
Analogy . . . . . . . . . . . . . . . . . . . . Analogous exposures for demonstrated outcomes.

OR—odds ratio; RCT—randomized controlled trial; RR—relative risk.

256 References
  1. Moutsopoulos, N.M.; Madianos, P.N. Low-grade inflammation in chronic infectious diseases: Paradigm of periodontal infections. Ann. N. Y. Acad. Sci. 2006,1088, 251-264. [CrossRef] [PubMed]
  2. Chapple, I.L.C.; Mealey, B.L.; Van Dyke, T.E.; Bartold, P.M.; Dommisch, H.; Eickholz, P.; Geisinger, M.L.; Genco, R.J.; Glogauer, M.; Goldstein, M.; et al. Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. J. Periodontol. 2018, 89 (Suppl. S1), S74-S84. [CrossRef] [PubMed]
  3. Radaic, A.; Kapila, Y.L. The oralome and its dysbiosis: New insights into oral microbiome-host interactions. Comput. Struct. Biotechnol. J. 2021,19,1335-1360. [CrossRef] [PubMed]
  4. Abdulkareem, A.A.; Al-Taweel, F.B.; Al-Sharqi, A.J.B.; Gul, S.S.; Sha, A.; Chapple, I.L.C. Current concepts in the pathogenesis of periodontitis: From symbiosis to dysbiosis. J. Oral Microbiol. 2023,15, 2197779. [CrossRef]
  5. Papapanou, P.N.; Sanz, M.; Buduneli, N.; Dietrich, T.; Feres, M.; Fine, D.H.; Flemmig, T.F.; Garcia, R.; Giannobile, W.V.; Graziani, F.; et al. Periodontitis: Consensus report of workgroup 2 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. J. Clin. Periodontol. 2018, 45 (Suppl. S20), S162-S170. [CrossRef]
  6. Kononen, E.; Gursoy, M.; Gursoy, U.K. Periodontitis: A Multifaceted Disease of Tooth-Supporting Tissues. J. Clin. Med. 2019, 8, 1135. [CrossRef]
  7. Najeeb, S.; Zafar, M.S.; Khurshid, Z.; Zohaib, S.; Almas, K. The Role of Nutrition in Periodontal Health: An Update. Nutrients 2016, 8, 530. [CrossRef]
  8. Takahashi, N.; Sulijaya, B.; Yamada-Hara, M.; Tsuzuno, T.; Tabeta, K.; Yamazaki, K. Gingival epithelial barrier: Regulation by beneficial and harmful microbes. Tissue Barriers 2019, 7, e1651158. [CrossRef]
  9. Park, D.Y.; Park, J.Y.; Lee, D.; Hwang, I.; Kim, H.S. Leaky Gum: The Revisited Origin of Systemic Diseases. Cells 2022,11,1079. [CrossRef]
  10. Vitkov, L.; Singh, J.; Schauer, C.; Minnich, B.; Krunic, J.; Oberthaler, H.; Gamsjaeger, S.; Herrmann, M.; Knopf, J.; Hannig, M. Breaking the Gingival Barrier in Periodontitis. Int. J. Mol. Sci. 2023, 24, 4544. [CrossRef]
  11. Cecoro, G.; Annunziata, M.; Iuorio, M.T.; Nastri, L.; Guida, L. Periodontitis, Low-Grade Inflammation and Systemic Health: A Scoping Review. Medicina 2020, 56, 272. [CrossRef] [PubMed]
  12. Nazir, M.; Al-Ansari, A.; Al-Khalifa, K.; Alhareky, M.; Gaffar, B.; Almas, K. Global Prevalence of Periodontal Disease and Lack of Its Surveillance. Sci. World J. 2020, 2020, 2146160. [CrossRef]
  13. Eke, P.I.; Borgnakke, W.S.; Genco, R.J. Recent epidemiologic trends in periodontitis in the USA. Periodontology 2020, 82, 257-267. [CrossRef] [PubMed]
  14. Grant, W.B.; Garland, C.F. The association of solar ultraviolet B (UVB) with reducing risk of cancer: Multifactorial ecologic analysis of geographic variation in age-adjusted cancer mortality rates. Anticancer Res. 2006, 26, 2687-2699.
  15. Kinane, D.F.; Chestnutt, I.G. Smoking and periodontal disease. Crit. Rev. Oral Biol. Med. 2000,11, 356-365. [CrossRef]
  16. Hujoel, P.P.; Lingstrom, P. Nutrition, dental caries and periodontal disease: A narrative review. J. Clin. Periodontol. 2017, 44 (Suppl. S18), S79-S84. [CrossRef] [PubMed]
  17. Chaffee, B.W.; Weston, S.J. Association between chronic periodontal disease and obesity: A systematic review and meta-analysis. J. Periodontol. 2010, 81,1708-1724. [CrossRef] [PubMed]
  18. Sanz, M.; Ceriello, A.; Buysschaert, M.; Chapple, I.; Demmer, R.T.; Graziani, F.; Herrera, D.; Jepsen, S.; Lione, L.; Madianos, P.; et al. Scientific evidence on the links between periodontal diseases and diabetes: Consensus report and guidelines of the joint workshop on periodontal diseases and diabetes by the International Diabetes Federation and the European Federation of Periodontology. J. Clin. Periodontol. 2018, 45,138-149. [CrossRef]
  19. Polak, D.; Sanui, T.; Nishimura, F.; Shapira, L. Diabetes as a risk factor for periodontal disease-plausible mechanisms. Periodontol- ogy 2020, 83, 46-58. [CrossRef]
  20. Ezzati, M.; Lopez, A.D. Regional, disease specific patterns of smoking-attributable mortality in 2000. Tob. Control 2004,13,388-395. [CrossRef]
  21. Jiang, C.; Chen, Q.; Xie, M. Smoking increases the risk of infectious diseases: A narrative review. Tob. Indue. Dis. 2020,18, 60. [CrossRef] [PubMed]
  22. Wang, P.; Song, M.; Eliassen, A.H.; Wang, M.; Fung, T.T.; Clinton, S.K.; Rimm, E.B.; Hu, F.B.; Willett, W.C.; Tabung, F.K.; et al. Optimal dietary patterns for prevention of chronic disease. Nat. Med. 2023,29, 719-728. [CrossRef] [PubMed]
  23. Nigro, E.; Scudiero, O.; Monaco, M.L.; Palmieri, A.; Mazzarella, G.; Costagliola, C.; Bianco, A.; Daniele, A. New insight into adiponectin role in obesity and obesity-related diseases. Biomed. Res. Int. 2014,2014, 658913. [CrossRef] [PubMed]
  24. Wlodarczyk, M.; Nowicka, G. Obesity, DNA Damage, and Development of Obesity-Related Diseases. Int. J. Mol. Sei. 2019, 20, 1146. [CrossRef]
  25. Shah, B.R.; Hux, J.E. Quantifying the risk of infectious diseases for people with diabetes. Diabetes Care 2003, 26, 510-513. [CrossRef]
  26. Giovannucci, E.; Harlan, D.M.; Archer, M.C.; Bergenstal, R.M.; Gapstur, S.M.; Habel, L.A.; Pollak, M.; Regensteiner, J.G.; Yee, D. Diabetes and cancer: A consensus report. CA Cancer J. Clin. 2010, 60, 207-221. [CrossRef]
  27. Habib, S.L.; Rojna, M. Diabetes and risk of cancer. ISRN Oneol. 2013, 2013, 583786. [CrossRef]
  28. Matheus, A.S.; Tannus, L.R.; Cobas, R.A.; Palma, C.C.; Negrato, C.A.; Gomes, M.B. Impact of diabetes on cardiovascular disease: An update. Int. J. Hypertens. 2013,2013, 653789. [CrossRef]
  29. Ferreira, R.O.; Correa, M.G.; Magno, M.B.; Almeida, A.; Fagundes, N.C.F.; Rosing, C.K.; Maia, L.C.; Lima, R.R. Physical Activity Reduces the Prevalence of Periodontal Disease: Systematic Review and Meta-Analysis. Front. Physiol. 2019,10, 234. [CrossRef]
  30. Manouchehr-Pour, M.; Bissada, N.F. Periodontal disease in juvenile and adult diabetic patients: A review of the literature. J. Am. Dent. Assoe. 1983,107, 766-770. [CrossRef]
  31. Williams, J.B. Diabetic periodontoclasia. JADA 1928,15, 523-529.
  32. Stahl, S.S.; Wisan, J.M.; Miller, S.C. The influence of systemic diseases on alveolar bone. J. Am. Dent. Assoe. 1952, 45, 277-283. [CrossRef]
  33. Loesche, W.J. Periodontal disease as a risk factor for heart disease. Compendium 1994,15, 976.
  34. Beck, J.; Garcia, R.; Heiss, G.; Vokonas, P.S.; Offenbacher, S. Periodontal Disease and Cardiovascular Disease. J. Periodontol. 1996, 67 (Suppl. S10), 1123-1137. [CrossRef]
  35. Hujoel, P.P. Does chronic periodontitis cause coronary heart disease? A review of the literature. J. Am. Dent. Assoe. 2002,133 (Suppl. S1), 31S-36S. [CrossRef] [PubMed]
  36. Pihlstrom, B.L.; Michalowicz, B.S.; Johnson, N.W. Periodontal diseases. Laneet 2005, 366,1809-1820. [CrossRef] [PubMed]
  37. Hujoel, P. Dietary carbohydrates and dental-systemic diseases. J. Dent. Res. 2009, 88, 490-502. [CrossRef] [PubMed]
  38. Cleave, T.L.; Campbell, G.D. Diet and diverticulitis. Br. Med. J. 1966, 2, 50-51. [CrossRef]
  39. Yudkin, J. Pure, White and Deadly: The Problem of Sugar; Davis-Pointer, Ltd.: Loondon, UK, 1972.
  40. Monsarrat, P.; Blaizot, A.; Kemoun, P.; Ravaud, P.; Nabet, C.; Sixou, M.; Vergnes, J.N. Clinical research activity in periodontal medicine: A systematic mapping of trial registers. J. Clin. Periodontol. 2016, 43, 390-400. [CrossRef]
  41. Kumar, P.S. From focal sepsis to periodontal medicine: A century of exploring the role of the oral microbiome in systemic disease. J. Physiol. 2017, 595, 465-476. [CrossRef]
  42. Slots, J. Periodontitis: Facts, fallacies and the future. Periodontology 2017, 75, 7-23. [CrossRef]
  43. Pihlstrom, B.L.; Hodges, J.S.; Michalowicz, B.; Wohlfahrt, J.C.; Garcia, R.I. Promoting oral health care because of its possible effect on systemic disease is premature and may be misleading. J. Am. Dent. Assoe. 2018,149, 401-403. [CrossRef] [PubMed]
  44. Beck, J.D.; Papapanou, P.N.; Philips, K.H.; Offenbacher, S. Periodontal Medicine: 100 Years of Progress. J. Dent. Res. 2019, 98, 1053-1062. [CrossRef]
  45. Bui, F.Q.; Almeida-da-Silva, C.L.C.; Huynh, B.; Trinh, A.; Liu, J.; Woodward, J.; Asadi, H.; Ojcius, D.M. Association between periodontal pathogens and systemic disease. Biomed. J. 2019, 42, 27-35. [CrossRef]
  46. Taylor, H.L.; Rahurkar, S.; Treat, T.J.; Thyvalikakath, T.P.; Schleyer, T.K. Does Nonsurgical Periodontal Treatment Improve Systemic Health? J. Dent. Res. 2021,100, 253-260. [CrossRef]
  47. Hill, A.B. The Environment and Disease: Association or Causation? Proe. R. Soe. Med. 1965, 58, 295-300. [CrossRef] [PubMed]
  48. Potischman, N.; Weed, D.L. Causal criteria in nutritional epidemiology. Am. J. Clin. Nutr. 1999, 69,1309S-1314S. [CrossRef] [PubMed]
  49. Lavigne, S.E.; Forrest, J.L. An umbrella review of systematic reviews of the evidence of a causal relationship between periodontal disease and cardiovascular diseases: Position paper from the Canadian Dental Hygienists Association. Can. J. Dent. Hyg. 2020,54, 32-41.
  50. Li, C.; Lv, Z.; Shi, Z.; Zhu, Y.; Wu, Y.; Li, L.; Iheozor-Ejiofor, Z. Periodontal therapy for the management of cardiovascular disease in patients with chronic periodontitis. Coehrane Database Syst. Rev. 2017,11, CD009197. [CrossRef]
  51. Lavigne, S.E.; Forrest, J.L. An umbrella review of systematic reviews examining the relationship between type 2 diabetes and periodontitis: Position paper from the Canadian Dental Hygienists Association. Can. J. Dent. Hyg. 2021, 55, 57-67.
  52. Lavigne, S.E.; Forrest, J.L. An umbrella review of systematic reviews of the evidence of a causal relationship between periodontal disease and adverse pregnancy outcomes: A position paper from the Canadian Dental Hygienists Association. Can. J. Dent. Hyg. 2020, 54, 92-100.
  53. Lavigne, S.E.; Forrest, J.L. An umbrella review of systematic reviews of the evidence of a causal relationship between periodontal microbes and respiratory diseases: Position paper from the Canadian Dental Hygienists Association. Can. J. Dent. Hyg. 2020, 54, 144-155.
  54. Lavigne, S.E. Evolving evidence for relationships between periodontitis and systemic diseases: Position paper from the Canadian Dental Hygienists Association. Can. J. Dent. Hyg. 2022, 56,155-171. [PubMed]
  55. Veazie, S.; Vela, K.; Parr, N.J. Evidence Brief: Detection and Treatment of Dental Problems on Chronic Disease Outcomes; Department of Veterans Affairs (US): Washington, DC, USA, 2021.
  56. Sanz, M.; del Castillo, A.M.; Jepsen, S.; Gonzalez-Juanatey, J.R.; D'Aiuto, F.; Bouchard, P.; Chapple, I.; Dietrich, T.; Gotsman, I.; Graziani, F.; et al. Periodontitis and cardiovascular diseases: Consensus report. J. Clin. Periodontol. 2020, 47, 268-288. [CrossRef]
  57. Herrera, D.; Sanz, M.; Shapira, L.; Brotons, C.; Chapple, I.; Frese, T.; Graziani, F.; Hobbs, F.D.R.; Huck, O.; Hummers, E.; et al. Association between periodontal diseases and cardiovascular diseases, diabetes and respiratory diseases: Consensus report of the Joint Workshop by the European Federation of Periodontology (EFP) and the European arm of the World Organization of Family Doctors (WONCA Europe). J. Clin. Periodontol. 2023, 50, 819-841. [CrossRef] [PubMed]
  58. Esposito, K.; Ciotola, M.; Carleo, D.; Schisano, B.; Sardelli, L.; Di Tommaso, D.; Misso, L.; Saccomanno, F.; Ceriello, A.; Giugliano, D. Post-meal glucose peaks at home associate with carotid intima-media thickness in type 2 diabetes. J. Clin. Endocrinol. Metab. 2008, 93,1345-1350. [CrossRef] [PubMed]
  59. Ceriello, A.; Esposito, K.; Piconi, L.; Ihnat, M.A.; Thorpe, J.E.; Testa, R.; Boemi, M.; Giugliano, D. Oscillating glucose is more deleterious to endothelial function and oxidative stress than mean glucose in normal and type 2 diabetic patients. Diabetes 2008, 57,1349-1354. [CrossRef] [PubMed]
  60. Engebretson, S.P.; Vossughi, F.; Hey-Hadavi, J.; Emingil, G.; Grbic, J.T. The influence of diabetes on gingival crevicular fluid beta-glucuronidase and interleukin-8. J. Clin. Periodontol. 2006, 33, 784-790. [CrossRef]
  61. Duarte, P.M.; Santos, V.R.; dos Santos, F.A.; de Lima Pereira, S.A.; Rodrigues, D.B.; Napimoga, M.H. Role of smoking and type 2 diabetes in the immunobalance of advanced chronic periodontitis. J. Periodontol. 2011, 82, 429-438. [CrossRef]
  62. Taylor, J.J.; Preshaw, P.M.; Lalla, E. A review of the evidence for pathogenic mechanisms that may link periodontitis and diabetes. J. Clin. Periodontol. 2013, 40 (Suppl. S14), S113-S134. [CrossRef]
  63. Emrich, L.J.; Shlossman, M.; Genco, R.J. Periodontal disease in non-insulin-dependent diabetes mellitus. J. Periodontol. 1991, 62, 123-131. [CrossRef] [PubMed]
  64. Oliver, R.C.; Tervonen, T. Diabetes-A Risk Factor for Periodontitis in Adults? J. Periodontol. 1994, 65 (Suppl. S5), 530-538. [CrossRef]
  65. Taylor, G.W.; Burt, B.A.; Becker, M.P.; Genco, R.J.; Shlossman, M.; Knowler, W.C.; Pettitt, D.J. Severe periodontitis and risk for poor glycemic control in patients with non-insulin-dependent diabetes mellitus. J. Periodontol. 1996, 67,1085-1093. [CrossRef]
  66. Preshaw, P.M.; Alba, A.L.; Herrera, D.; Jepsen, S.; Konstantinidis, A.; Makrilakis, K.; Taylor, R. Periodontitis and diabetes: A two-way relationship. Diabetologia 2012, 55, 21-31. [CrossRef] [PubMed]
  67. Schwingshackl, L.; Hoffmann, G.; Lampousi, A.M.; Knuppel, S.; Iqbal, K.; Schwedhelm, C.; Bechthold, A.; Schlesinger, S.; Boeing, H. Food groups and risk of type 2 diabetes mellitus: A systematic review and meta-analysis of prospective studies. Eur. J. Epidemiol. 2017, 32, 363-375. [CrossRef]
  68. O'Hearn, M.; Lara-Castor, L.; Cudhea, F.; Miller, V.; Reedy, J.; Shi, P.; Zhang, J.; Wong, J.B.; Economos, C.D.; Micha, R.; et al. Incident type 2 diabetes attributable to suboptimal diet in 184 countries. Nat. Med. 2023,29, 982-995. [CrossRef] [PubMed]
  69. Nishida, M.; Grossi, S.G.; Dunford, R.G.; Ho, A.W.; Trevisan, M.; Genco, R.J. Calcium and the risk for periodontal disease. J. Periodontol. 2000, 71,1057-1066. [CrossRef]
  70. Petersen, P.E.; Ogawa, H. Strengthening the prevention of periodontal disease: The WHO approach. J. Periodontol. 2005, 76, 2187-2193. [CrossRef]
  71. Merchant, A.T.; Pitiphat, W.; Franz, M.; Joshipura, K.J. Whole-grain and fiber intakes and periodontitis risk in men. Am. J. Clin. Nutr. 2006, 83,1395-1400. [CrossRef]
  72. Al-Zahrani, M.S. Increased intake of dairy products is related to lower periodontitis prevalence. J. Periodontol. 2006, 77, 289-294. [CrossRef]
  73. Morillo, J.M.; Bullon, P.; Ramirez-Tortosa, M.C.; Quiles, J.L.; Newman, H.N.; Bertoli, E.; Battino, M. Nutrition-linked chronic disease and periodontitis: Are they the two faces of the same coin? Mediterr. J. Nutr. Metab. 2009,2,103-109. [CrossRef]
  74. Yoshihara, A.; Watanabe, R.; Hanada, N.; Miyazaki, H. A longitudinal study of the relationship between diet intake and dental caries and periodontal disease in elderly Japanese subjects. Gerodontology 2009, 26,130-136. [CrossRef]
  75. Iwasaki, M.; Yoshihara, A.; Moynihan, P.; Watanabe, R.; Taylor, G.W.; Miyazaki, H. Longitudinal relationship between dietary omega-3 fatty acids and periodontal disease. Nutrition 2010,26,1105-1109. [CrossRef]
  76. Staufenbiel, I.; Weinspach, K.; Forster, G.; Geurtsen, W.; Gunay, H. Periodontal conditions in vegetarians: A clinical study. Eur. J. Clin. Nutr. 2013, 67, 836-840. [CrossRef] [PubMed]
  77. Song, I.S.; Han, K.; Park, Y.M.; Ji, S.; Jun, S.H.; Ryu, J.J.; Park, J.B. Severe Periodontitis Is Associated with Insulin Resistance in Non-abdominal Obese Adults. J. Clin. Endocrinol. Metab. 2016,101, 4251-4259. [CrossRef] [PubMed]
  78. Salazar, C.R.; Laniado, N.; Mossavar-Rahmani, Y.; Borrell, L.N.; Qi, Q.; Sotres-Alvarez, D.; Morse, D.E.; Singer, R.H.; Kaplan, R.C.; Badner, V.; et al. Better-quality diet is associated with lower odds of severe periodontitis in US Hispanics/Latinos. J. Clin. Periodontol. 2018, 45, 780-790. [CrossRef] [PubMed]
  79. Chiuve, S.E.; Fung, T.T.; Rimm, E.B.; Hu, F.B.; McCullough, M.L.; Wang, M.; Stampfer, M.J.; Willett, W.C. Alternative dietary indices both strongly predict risk of chronic disease. J. Nutr. 2012,142,1009-1018. [CrossRef]
  80. Atarbashi-Moghadam, F.; Moallemi-Pour, S.; Atarbashi-Moghadam, S.; Sijanivandi, S.; Baghban, A.A. Effects of raw vegan diet on periodontal and dental parameters. Tzu Chi Med. J. 2020, 32, 357-361. [CrossRef]
  81. Jauhiainen, L.M.; Ylostalo, P.V.; Knuuttila, M.; Mannisto, S.; Kanerva, N.; Suominen, A.L. Poor diet predicts periodontal disease development in 11-year follow-up study. Community Dent. Oral Epidemiol. 2020, 48,143-151. [CrossRef]
  82. Alhassani, A.A.; Hu, F.B.; Rimm, E.B.; Li, Y.; Rosner, B.A.; Willett, W.C.; Joshipura, K.J. Dietary flavonoid intake and risk of periodontitis. J. Periodontol. 2020, 91,1057-1066. [CrossRef]
  83. Barbaresko, J.; Koch, M.; Schulze, M.B.; Nothlings, U. Dietary pattern analysis and biomarkers of low-grade inflammation: A systematic literature review. Nutr. Rev. 2013, 71, 511-527. [CrossRef] [PubMed]
  84. Koh-Banerjee, P.; Wang, Y.; Hu, F.B.; Spiegelman, D.; Willett, W.C.; Rimm, E.B. Changes in body weight and body fat distribution as risk factors for clinical diabetes in US men. Am. J. Epidemiol. 2004,159,1150-1159. [CrossRef] [PubMed]
  85. Esmaillzadeh, A.; Kimiagar, M.; Mehrabi, Y.; Azadbakht, L.; Hu, F.B.; Willett, W.C. Dietary patterns, insulin resistance, and prevalence of the metabolic syndrome in women. Am. J. Clin. Nutr. 2007, 85, 910-918. [CrossRef]
  86. Martinon, P.; Fraticelli, L.; Giboreau, A.; Dussart, C.; Bourgeois, D.; Carrouel, F. Nutrition as a Key Modifiable Factor for Periodontitis and Main Chronic Diseases. J. Clin. Med. 2021,10,197. [CrossRef] [PubMed]
  87. Shivappa, N.; Steck, S.E.; Hurley, T.G.; Hussey, J.R.; Hebert, J.R. Designing and developing a literature-derived, population-based dietary inflammatory index. Public Health Nutr. 2014,17,1689-1696. [CrossRef]
  88. Machado, V.; Botelho, J.; Viana, J.; Pereira, P.; Lopes, L.B.; Proenca, L.; Delgado, A.S.; Mendes, J.J. Association between Dietary Inflammatory Index and Periodontitis: A Cross-Sectional and Mediation Analysis. Nutrients 2021,13,1194. [CrossRef]
  89. Choi, S.W.; Sreeja, S.R.; Le, T.D.; Shivappa, N.; Hebert, J.R.; Kim, M.K. Association between inflammatory potential of diet and periodontitis disease risks: Results from a Korean population-based cohort study. J. Clin. Periodontol. 2023,50, 952-963. [CrossRef]
  90. Alhassani, A.A.; Hu, F.B.; Rosner, B.A.; Tabung, F.K.; Willett, W.C.; Joshipura, K.J. The relationship between inflammatory dietary pattern and incidence of periodontitis. Br. J. Nutr. 2021,126,1698-1708. [CrossRef]
  91. Sáenz-Ravello, G.; Matamala, L.; dos Santos, N.C.; Cisternas, P.; Gamonal, J.; Fernandez, A.; Bello-Escamilla, N.; Hernandez, M.; Baeza, M. Healthy Dietary Patterns on Clinical Periodontal Parameters: A GRADE Compliant Systematic Review and Meta-analysis. Curr. Oral Health Rep. 2022, 9, 32-55. [CrossRef]
  92. Li, A.; Qiu, B.; Goettsch, M.; Chen, Y.; Ge, S.; Xu, S.; Tjakkes, G.E. Association between the quality of plant-based diets and periodontitis in the U.S. general population. J. Clin. Periodontol. 2023, 50, 591-603. [CrossRef]
  93. Rhee, J.J.; Mattei, J.; Hughes, M.D.; Hu, F.B.; Willett, W.C. Dietary diabetes risk reduction score, race and ethnicity, and risk of type 2 diabetes in women. Diabetes Care 2015, 38, 596-603. [CrossRef]
  94. Asensi, M.T.; Napoletano, A.; Sofi, F.; Diun, M. Low-Grade Inflammation and Ultra-Processed Foods Consumption: A Review. Nutrients 2023,15,1546. [CrossRef]
  95. Askari, M.; Heshmati, J.; Shahinfar, H.; Tripathi, N.; Daneshzad, E. Ultra-processed food and the risk of overweight and obesity: A systematic review and meta-analysis of observational studies. Int. J. Obes. 2020, 44, 2080-2091. [CrossRef]
  96. Calder, P.C.; Ahluwalia, N.; Brouns, F.; Buetler, T.; Clement, K.; Cunningham, K.; Esposito, K.; Jonsson, L.S.; Kolb, H.; Lansink, M.; et al. Dietary factors and low-grade inflammation in relation to overweight and obesity. Br. J. Nutr. 2011,106 (Suppl. S3), S5-S78. [CrossRef]
  97. Donat-Vargas, C.; Sandoval-Insausti, H.; Rey-Garcia, J.; Moreno-Franco, B.; Akesson, A.; Banegas, J.R.; Rodriguez-Artalejo, F.; Guallar-Castillon, P. High Consumption of Ultra-Processed Food is Associated with Incident Dyslipidemia: A Prospective Study of Older Adults. J. Nutr. 2021,151, 2390-2398. [CrossRef]
  98. Mazidi, M.; Valdes, A.M.; Ordovas, J.M.; Hall, W.L.; Pujol, J.C.; Wolf, J.; Hadjigeorgiou, G.; Segata, N.; Sattar, N.; Koivula, R.; et al. Meal-induced inflammation: Postprandial insights from the Personalised REsponses to DIetary Composition Trial (PREDICT) study in 1000 participants. Am. J. Clin. Nutr. 2021,114,1028-1038. [CrossRef]
  99. Ultra-Processed Foods: A Global Threat to Public Health; UNC Global Food Research Program, University of North Carolina at Chappel Hill: Chapple Hill, NC, USA, 2021; p. 10.
  100. Llavero-Valero, M.; Escalada-San Martin, J.; Martinez-Gonzalez, M.A.; Basterra-Gortari, F.J.; de la Fuente-Arrillaga, C.; Bes- Rastrollo, M. Ultra-processed foods and type-2 diabetes risk in the SUN project: A prospective cohort study. Clin. Nutr. 2021, 40, 2817-2824. [CrossRef]
  101. Cassiano, L.S.; Peres, M.A.; Motta, J.V.S.; Demarco, F.F.; Horta, B.L.; Ribeiro, C.C.; Nascimento, G.G. Periodontitis Is Associated with Consumption of Processed and Ultra-Processed Foods: Findings from a Population-Based Study. Nutrients 2022,14, 3735. [CrossRef] [PubMed]
  102. Mendonca, R.D.; Pimenta, A.M.; Gea, A.; de la Fuente-Arrillaga, C.; Martinez-Gonzalez, M.A.; Lopes, A.C.; Bes-Rastrollo, M. Ultraprocessed food consumption and risk of overweight and obesity: The University of Navarra Follow-Up (SUN) cohort study. Am. J. Clin. Nutr. 2016,104,1433-1440. [CrossRef] [PubMed]
  103. Canhada, S.L.; Luft, V.C.; Giatti, L.; Duncan, B.B.; Chor, D.; Fonseca, M.; Matos, S.M.A.; Molina, M.; Barreto, S.M.; Levy, R.B.; et al. Ultra-processed foods, incident overweight and obesity, and longitudinal changes in weight and waist circumference: The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Public Health Nutr. 2020,23,1076-1086. [CrossRef] [PubMed]
  104. Pagliai, G.; Dinu, M.; Madarena, M.P.; Bonaccio, M.; Iacoviello, L.; Sofi, F. Consumption of ultra-processed foods and health status: A systematic review and meta-analysis. Br. J. Nutr. 2021,125, 308-318. [CrossRef]
  105. Bonaccio, M.; di Castelnuovo, A.; Costanzo, S.; de Curtis, A.; Persichillo, M.; Sofi, F.; Cerletti, C.; Donati, M.B.; de Gaetano, G.; Iacoviello, L. Ultra-processed food consumption is associated with increased risk of all-cause and cardiovascular mortality in the Moli-sani Study. Am. J. Clin. Nutr. 2021,113, 446-455. [CrossRef]
  106. Fiolet, T.; Srour, B.; Sellem, L.; Kesse-Guyot, E.; Alles, B.; Mejean, C.; Deschasaux, M.; Fassier, P.; Latino-Martel, P.; Beslay, M.; et al. Consumption of ultra-processed foods and cancer risk: Results from NutriNet-Sante prospective cohort. BMJ 2018, 360, k322. [CrossRef]
  107. Yang, J.J.; Shu, X.O.; Herrington, D.M.; Moore, S.C.; Meyer, K.A.; Ose, J.; Menni, C.; Palmer, N.D.; Eliassen, H.; Harada, S.; et al. Circulating trimethylamine N-oxide in association with diet and cardiometabolic biomarkers: An international pooled analysis. Am. J. Clin. Nutr. 2021,113,1145-1156. [CrossRef]
  108. Zhou, J.; Chen, S.; Ren, J.; Zou, H.; Liu, Y.; Chen, Y.; Qiu, Y.; Zhuang, W.; Tao, J.; Yang, J. Association of enhanced circulating trimethylamine N-oxide with vascular endothelial dysfunction in periodontitis patients. J. Periodontol. 2022, 93, 770-779. [CrossRef]
  109. Wang, Q.; Sun, Y.; Zhou, T.; Jiang, C.; A, L.; Xu, W. Gut microbiota-dependent trimethylamine n-oxide pathway contributes to the bidirectional relationship between intestinal inflammation and periodontitis. Front. Cell. Infect. Microbiol. 2022,12,1125463. [CrossRef] [PubMed]
  110. Gao, Q.; Wang, Y.; Wang, X.; Fu, S.; Zhang, X.; Wang, R.T.; Zhang, X. Decreased levels of circulating trimethylamine N-oxide alleviate cognitive and pathological deterioration in transgenic mice: A potential therapeutic approach for Alzheimer's disease. Aging 2019,11, 8642-8663. [CrossRef] [PubMed]
  111. Buawangpong, N.; Pinyopornpanish, K.; Siri-Angkul, N.; Chattipakorn, N.; Chattipakorn, S.C. The role of trimethylamine-N- Oxide in the development of Alzheimer's disease. J. Cell. Physiol. 2022,237,1661-1685. [CrossRef]
  112. Arrona Cardoza, P.; Spillane, M.B.; Morales Marroquin, E. Alzheimer's disease and gut microbiota: Does trimethylamine N-oxide (TMAO) play a role? Nutr. Rev. 2022, 80, 271-281. [CrossRef]
  113. Croyal, M.; Saulnier, P.J.; Aguesse, A.; Gand, E.; Ragot, S.; Roussel, R.; Halimi, J.M.; Ducrocq, G.; Cariou, B.; Montaigne, D.; et al. Plasma Trimethylamine N-Oxide and Risk of Cardiovascular Events in Patients with Type 2 Diabetes. J. Clin. Endocrinol. Metab. 2020,105, 2371-2380. [CrossRef] [PubMed]
  114. Thomas, M.S.; Fernandez, M.L. Trimethylamine N-Oxide (TMAO), Diet and Cardiovascular Disease. Curr. Atheroscler. Rep. 2021, 23, 12. [CrossRef] [PubMed]
  115. Grinberga, S.; Dambrova, M.; Latkovskis, G.; Strele, I.; Konrade, I.; Hartmane, D.; Sevostjanovs, E.; Liepinsh, E.; Pugovics, O. Determination of trimethylamine-N-oxide in combination with L-carnitine and gamma-butyrobetaine in human plasma by UPLC/MS/MS. Biomed. Chromatogr. 2015, 29,1670-1674. [CrossRef] [PubMed]
  116. Shao, J.; Wu, L.; Leng, W.D.; Fang, C.; Zhu, Y.J.; Jin, Y.H.; Zeng, X.T. Periodontal Disease and Breast Cancer: A Meta-Analysis of 173,162 Participants. Front. Oncol. 2018, 8, 601. [CrossRef] [PubMed]
  117. Constantino-Jonapa, L.A.; Espinoza-Palacios, Y.; Escalona-Montano, A.R.; Hernandez-Ruiz, P.; Amezcua-Guerra, L.M.; Amedei, A.; Aguirre-Garcia, M.M. Contribution of Trimethylamine N-Oxide (TMAO) to Chronic Inflammatory and Degenerative Diseases. Biomedicines 2023,11, 431. [CrossRef] [PubMed]
  118. Zyriax, B.C.; Boeing, H.; Windler, E. Nutrition is a powerful independent risk factor for coronary heart disease in women—The CORA study: A population-based case-control study. Eur. J. Clin. Nutr. 2005, 59,1201-1207. [CrossRef] [PubMed]
  119. Papier, K.; Knuppel, A.; Syam, N.; Jebb, S.A.; Key, T.J. Meat consumption and risk of ischemic heart disease: A systematic review and meta-analysis. Crit. Rev. Food Sci. Nutr. 2023, 63, 426-437. [CrossRef]
  120. Anderson, J.W.; Ward, K. High-carbohydrate, high-fiber diets for insulin-treated men with diabetes mellitus. Am. J. Clin. Nutr. 1979, 32, 2312-2321. [CrossRef]
  121. Barnard, N.D.; Cohen, J.; Jenkins, D.J.; Turner-McGrievy, G.; Gloede, L.; Jaster, B.; Seidl, K.; Green, A.A.; Talpers, S. A low-fat vegan diet improves glycemic control and cardiovascular risk factors in a randomized clinical trial in individuals with type 2 diabetes. Diabetes Care 2006, 29,1777-1783. [CrossRef]
  122. American Dietetic Association; Dietitians of Canada. Position of the American Dietetic Association and Dietitians of Canada: Vegetarian diets. J. Am. Diet. Assoc. 2003,103, 748-765. [CrossRef]
  123. Kwon, Y.J.; Lee, H.S.; Park, J.Y.; Lee, J.W. Associating Intake Proportion of Carbohydrate, Fat, and Protein with All-Cause Mortality in Korean Adults. Nutrients 2020,12, 3208. [CrossRef]
  124. Tonstad, S.; Butler, T.; Yan, R.; Fraser, G.E. Type of vegetarian diet, body weight, and prevalence of type 2 diabetes. Diabetes Care 2009, 32, 791-796. [CrossRef]
  125. Satija, A.; Bhupathiraju, S.N.; Rimm, E.B.; Spiegelman, D.; Chiuve, S.E.; Borgi, L.; Willett, W.C.; Manson, J.E.; Sun, Q.; Hu, F.B. Plant-Based Dietary Patterns and Incidence of Type 2 Diabetes in US Men and Women: Results from Three Prospective Cohort Studies. PLoS Med. 2016,13, e1002039. [CrossRef]
  126. McMacken, M.; Shah, S. A plant-based diet for the prevention and treatment of type 2 diabetes. J. Geriatr. Cardiol. 2017, 14, 342-354. [CrossRef]
  127. Kelly, J.; Karlsen, M.; Steinke, G. Type 2 Diabetes Remission and Lifestyle Medicine: A Position Statement From the American College of Lifestyle Medicine. Am. J. Lifestyle Med. 2020,14, 406-419. [CrossRef]
  128. Jardine, M.A.; Kahleova, H.; Levin, S.M.; Ali, Z.; Trapp, C.B.; Barnard, N.D. Perspective: Plant-Based Eating Pattern for Type 2 Diabetes Prevention and Treatment: Efficacy, Mechanisms, and Practical Considerations. Adv. Nutr. 2021, 12, 2045-2055. [CrossRef]
  129. Chen, Z.; Drouin-Chartier, J.P.; Li, Y.; Baden, M.Y.; Manson, J.E.; Willett, W.C.; Voortman, T.; Hu, F.B.; Bhupathiraju, S.N. Changes in Plant-Based Diet Indices and Subsequent Risk of Type 2 Diabetes in Women and Men: Three U.S. Prospective Cohorts. Diabetes Care 2021, 44, 663-671. [CrossRef] [PubMed]
  130. Lagana, A.S.; Vitale, S.G.; Ban Frangez, H.; Vrtacnik-Bokal, E.; D'Anna, R. Vitamin D in human reproduction: The more, the better? An evidence-based critical appraisal. Eur. Rev. Med. Pharmacol. Sci. 2017, 21, 4243-4251.
  131. Zehnder, D.; Bland, R.; Williams, M.C.; McNinch, R.W.; Howie, A.J.; Stewart, P.M.; Hewison, M. Extrarenal expression of 25-hydroxyvitamin d(3)-1 alpha-hydroxylase. J. Clin. Endocrinol. Metab. 2001, 86, 888-894. [CrossRef]
  132. Shirvani, A.; Kalajian, T.A.; Song, A.; Holick, M.F. Disassociation of Vitamin D's Calcemic Activity and Non-calcemic Genomic Activity and Individual Responsiveness: A Randomized Controlled Double-Blind Clinical Trial. Sci. Rep. 2019, 9, 17685. [CrossRef]
  133. Holick, M.F. Vitamin D: A d-lightful solution for health. J. Investig. Med. 2011, 59, 872-880. [CrossRef] [PubMed]
  134. McCullough, P.J.; Lehrer, D.S.; Amend, J. Daily oral dosing of vitamin D3 using 5000 TO 50,000 international units a day in long-term hospitalized patients: Insights from a seven year experience. J. Steroid Biochem. Mol. Biol. 2019,189, 228-239. [CrossRef]
  135. Tebben, P.J.; Singh, R.J.; Kumar, R. Vitamin D-Mediated Hypercalcemia: Mechanisms, Diagnosis, and Treatment. Endocr. Rev. 2016, 37, 521-547. [CrossRef]
  136. Araki, T.; Holick, M.F.; Alfonso, B.D.; Charlap, E.; Romero, C.M.; Rizk, D.; Newman, L.G. Vitamin D intoxication with severe hypercalcemia due to manufacturing and labeling errors of two dietary supplements made in the United States. J. Clin. Endocrinol. Metab. 2011, 96, 3603-3608. [CrossRef]
  137. Charoenngam, N.; Shirvani, A.; Holick, M.F. Vitamin D for skeletal and non-skeletal health: What we should know. J. Clin. Orthop. Trauma 2019,10,1082-1093. [CrossRef]
  138. Charoenngam, N.; Holick, M.F. Immunologic Effects of Vitamin D on Human Health and Disease. Nutrients 2020, 12, 2097. [CrossRef]
  139. Athanassiou, L.; Kostoglou-Athanassiou, I.; Koutsilieris, M.; Shoenfeld, Y. Vitamin D and Autoimmune Rheumatic Diseases. Biomolecules 2023,13, 709. [CrossRef]
  140. Muñoz, A.; Grant, W.B. Vitamin D and Cancer: An Historical Overview of the Epidemiology and Mechanisms. Nutrients 2022,14, 1448. [CrossRef]
  141. de la Guia-Galipienso, F.; Martinez-Ferran, M.; Vallecillo, N.; Lavie, C.J.; Sanchis-Gomar, F.; Pareja-Galeano, H. Vitamin D and cardiovascular health. Clin. Nutr. 2021, 40, 2946-2957. [CrossRef]
  142. Gombart, A.F. The vitamin D-antimicrobial peptide pathway and its role in protection against infection. Future Microbiol. 2009, 4, 1151-1165. [CrossRef] [PubMed]
  143. Mailhot, G.; White, J.H. Vitamin D and Immunity in Infants and Children. Nutrients 2020,12,1233. [CrossRef] [PubMed]
  144. Ahmed, F. A Network-Based Analysis Reveals the Mechanism Underlying Vitamin D in Suppressing Cytokine Storm and Virus in SARS-CoV-2 Infection. Front. Immunol. 2020,11, 590459. [CrossRef]
  145. Guillot, X.; Semerano, L.; Saidenberg-Kermanac'h, N.; Falgarone, G.; Boissier, M.C. Vitamin D and inflammation. Jt. Bone Spine 2010, 77, 552-557. [CrossRef]
  146. Szymczak-Pajor, I.; Drzewoski, J.; Sliwinska, A. The Molecular Mechanisms by Which Vitamin D Prevents Insulin Resistance and Associated Disorders. Int. J. Mol. Sci. 2020,21, 6644. [CrossRef]
  147. Dzik, K.P.; Kaczor, J.J. Mechanisms of vitamin D on skeletal muscle function: Oxidative stress, energy metabolism and anabolic state. Eur. J. Appl. Physiol. 2019,119, 825-839. [CrossRef]
  148. Karras, S.N.; Wagner, C.L.; Castracane, V.D. Understanding vitamin D metabolism in pregnancy: From physiology to pathophysi­ology and clinical outcomes. Metabolism 2018, 86,112-123. [CrossRef]
  149. Hypponen, E.; Power, C. Hypovitaminosis D in British adults at age 45 y: Nationwide cohort study of dietary and lifestyle predictors. Am. J. Clin. Nutr. 2007, 85, 860-868. [CrossRef]
  150. Kroll, M.H.; Bi, C.; Garber, C.C.; Kaufman, H.W.; Liu, D.; Caston-Balderrama, A.; Zhang, K.; Clarke, N.; Xie, M.; Reitz, R.E.; et al. Temporal relationship between vitamin D status and parathyroid hormone in the United States. PLoS ONE 2015,10, e0118108. [CrossRef]
  151. Engelsen, O. The relationship between ultraviolet radiation exposure and vitamin D status. Nutrients 2010, 2,482-495. [CrossRef] [PubMed]
  152. Webb, A.R.; Kline, L.; Holick, M.F. Influence of season and latitude on the cutaneous synthesis of vitamin D3: Exposure to winter sunlight in Boston and Edmonton will not promote vitamin D3 synthesis in human skin. J. Clin. Endocrinol. Metab. 1988, 67, 373-378. [CrossRef] [PubMed]
  153. Mason, R.S.; Rybchyn, M.S.; Abboud, M.; Brennan-Speranza, T.C.; Fraser, D.R. The Role of Skeletal Muscle in Maintaining Vitamin D Status in Winter. Curr. Dev. Nutr. 2019, 3, nzz087. [CrossRef] [PubMed]
  154. Rybchyn, M.S.; Abboud, M.; Puglisi, D.A.; Gordon-Thomson, C.; Brennan-Speranza, T.C.; Mason, R.S.; Fraser, D.R. Skeletal Muscle and the Maintenance of Vitamin D Status. Nutrients 2020,12, 3270. [CrossRef]
  155. Martinaityte, I.; Kamycheva, E.; Didriksen, A.; Jakobsen, J.; Jorde, R. Vitamin D Stored in Fat Tissue During a 5-Year Intervention Affects Serum 25-Hydroxyvitamin D Levels the Following Year. J. Clin. Endocrinol. Metab. 2017,102, 3731-3738. [CrossRef]
  156. Crowe, F.L.; Steur, M.; Allen, N.E.; Appleby, P.N.; Travis, R.C.; Key, T.J. Plasma concentrations of 25-hydroxyvitamin D in meat eaters, fish eaters, vegetarians and vegans: Results from the EPIC-Oxford study. Public Health Nutr. 2011,14,340-346. [CrossRef] [PubMed]
  157. Chalcraft, J.R.; Cardinal, L.M.; Wechsler, P.J.; Hollis, B.W.; Gerow, K.G.; Alexander, B.M.; Keith, J.F.; Larson-Meyer, D.E. Vitamin D Synthesis Following a Single Bout of Sun Exposure in Older and Younger Men and Women. Nutrients 2020,12, 2237. [CrossRef] [PubMed]
  158. Li, W.; Zheng, Q.; Xu, M.; Zeng, C.; Deng, X. Association between circulating 25-hydroxyvitamin D metabolites and periodontitis: Results from the NHANES 2009-2012 and Mendelian randomization study. J. Clin. Periodontol. 2023, 50, 252-264. [CrossRef] [PubMed]
  159. Peric, M.; Maiter, D.; Cavalier, E.; Lasserre, J.F.; Toma, S. The Effects of 6-Month Vitamin D Supplementation during the Non- Surgical Treatment of Periodontitis in Vitamin-D-Deficient Patients: A Randomized Double-Blind Placebo-Controlled Study. Nutrients 2020,12, 2940. [CrossRef]
  160. Bashutski, J.D.; Eber, R.M.; Kinney, J.S.; Benavides, E.; Maitra, S.; Braun, T.M.; Giannobile, W.V.; McCauley, L.K. The impact of vitamin D status on periodontal surgery outcomes. J. Dent. Res. 2011, 90,1007-1012. [CrossRef]
  161. Hiremath, V.P.; Rao, C.B.; Naik, V.; Prasad, K.V. Anti-inflammatory effect of vitamin D on gingivitis: A dose-response randomised control trial. Oral Health Prev. Dent. 2013,11,61-69. [CrossRef]
  162. Assaf, M.; Aboelsaad, N. The Effectiveness of Vitamin D Supplementation in Chronic Periodontitis Patients: A Randomized Controlled Clinical Trial. Egypt. Dent. J. 2019, 65,1311-1321.
  163. Gao, W.; Tang, H.; Wang, D.; Zhou, X.; Song, Y.; Wang, Z. Effect of short-term vitamin D supplementation after nonsurgical periodontal treatment: A randomized, double-masked, placebo-controlled clinical trial. J. Periodontal Res. 2020, 55, 354-362. [CrossRef]
  164. Nesterova, O.; Krasilnikova, V.; Margaryan, E.; Lazareva, Y.; Nemtyreva, L. Treatment of chronic generalized periodontitis in patients with underlying hypovitaminosis D: Randomized comparative clinical trial. J. Appl. Oral Sci. 2022, 30, e20220335. [CrossRef]
  165. Bayirli, B.A.; Ozturk, A.; Avci, B. Serum vitamin D concentration is associated with antimicrobial peptide level in periodontal diseases. Arch. Oral Biol. 2020,117,104827. [CrossRef]
  166. Botelho, J.; Machado, V.; Proenca, L.; Delgado, A.S.; Mendes, J.J. Vitamin D Deficiency and Oral Health: A Comprehensive Review. Nutrients 2020,12,1471. [CrossRef]
  167. Nilsson, B.O. Mechanisms involved in regulation of periodontal ligament cell production of pro-inflammatory cytokines: Implications in periodontitis. J. Periodontal Res. 2021, 56, 249-255. [CrossRef]
  168. Lu, E.M. The role of vitamin D in periodontal health and disease. J. Periodontal Res. 2022, 58, 213-224. [CrossRef]
  169. Ustianowski, L.; Ustianowska, K.; Gurazda, K.; Rusinski, M.; Ostrowski, P.; Pawlik, A. The Role of Vitamin C and Vitamin D in the Pathogenesis and Therapy of Periodontitis-Narrative Review. Int. J. Mol. Sci. 2023, 24, 6774. [CrossRef]
  170. Foster, B.L.; Nociti, F.H., Jr.; Somerman, M.J. The rachitic tooth. Endocr. Rev. 2014, 35,1-34. [CrossRef]
  171. Feng, Z.; Weinberg, A. Role of bacteria in health and disease of periodontal tissues. Periodontology 2006, 40, 50-76. [CrossRef]
  172. Liu, P.T.; Stenger, S.; Li, H.; Wenzel, L.; Tan, B.H.; Krutzik, S.R.; Ochoa, M.T.; Schauber, J.; Wu, K.; Meinken, C.; et al. Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science 2006, 311,1770-1773. [CrossRef]
  173. Bikle, D.D. Vitamin D and the immune system: Role in protection against bacterial infection. Curr. Opin. Nephrol. Hypertens. 2008, 17, 348-352. [CrossRef]
  174. Costantini, E.; Sinjari, B.; Piscopo, F.; Porreca, A.; Reale, M.; Caputi, S.; Murmura, G. Evaluation of Salivary Cytokines and Vitamin D Levels in Periodontopathic Patients. Int. J. Mol. Sci. 2020, 21, 2669. [CrossRef]
  175. Bonnet, C.; Rabbani, R.; Moffatt, M.E.K.; Kelekis-Cholakis, A.; Schroth, R.J. The Relation Between Periodontal Disease and Vitamin D. J. Can. Dent. Assoc. 2019, 84, j4.
  176. Khammissa, R.A.G.; Ballyram, R.; Jadwat, Y.; Fourie, J.; Lemmer, J.; Feller, L. Vitamin D Deficiency as It Relates to Oral Immunity and Chronic Periodontitis. Int. J. Dent. 2018,2018, 7315797. [CrossRef]
  177. Batool, H.; Nadeem, A.; Kashif, M.; Shahzad, F.; Tahir, R.; Afzal, N. Salivary Levels of IL-6 and IL-17 Could Be an Indicator of Disease Severity in Patients with Calculus Associated Chronic Periodontitis. Biomed. Res. Int. 2018,2018, 8531961. [CrossRef]
  178. Jing, L.; Kim, S.; Sun, L.; Wang, L.; Mildner, E.; Divaris, K.; Jiao, Y.; Offenbacher, S. IL-37- and IL-35/IL-37-Producing Plasma Cells in Chronic Periodontitis. J. Dent. Res. 2019, 98, 813-821. [CrossRef]
  179. Luchian, I.; Goriuc, A.; Sandu, D.; Covasa, M. The Role of Matrix Metalloproteinases (MMP-8, MMP-9, MMP-13) in Periodontal and Peri-Implant Pathological Processes. Int. J. Mol. Sci. 2022, 23,1806. [CrossRef]
  180. Timms, P.M.; Mannan, N.; Hitman, G.A.; Noonan, K.; Mills, P.G.; Syndercombe-Court, D.; Aganna, E.; Price, C.P.; Boucher, B.J. Circulating MMP9, vitamin D and variation in the TIMP-1 response with VDR genotype: Mechanisms for inflammatory damage in chronic disorders? QJM 2002, 95, 787-796. [CrossRef]
  181. Sorsa, T.; Alassiri, S.; Grigoriadis, A.; Raisanen, I.T.; Parnanen, P.; Nwhator, S.O.; Gieselmann, D.R.; Sakellari, D. Active MMP-8 (aMMP-8) as a Grading and Staging Biomarker in the Periodontitis Classification. Diagnostics 2020,10, 61. [CrossRef]
  182. Machado, V.; Lobo, S.; Proenca, L.; Mendes, J.J.; Botelho, J. Vitamin D and Periodontitis: A Systematic Review and Meta-Analysis. Nutrients 2020,12, 2177. [CrossRef]
  183. Hans, M.; Malik, P.K.; Hans, V.M.; Chug, A.; Kumar, M. Serum levels of various vitamins in periodontal health and disease—A cross sectional study. J. Oral Biol. Craniofacial Res. 2023,13, 471-475. [CrossRef]
  184. Isola, G.; Alibrandi, A.; Rapisarda, E.; Matarese, G.; Williams, R.C.; Leonardi, R. Association of vitamin D in patients with periodontitis: A cross-sectional study. J. Periodontal Res. 2020, 55, 602-612. [CrossRef]
  185. Ketharanathan, V.; Torgersen, G.R.; Petrovski, B.E.; Preus, H.R. Radiographic alveolar bone level and levels of serum 25-OH- Vitamin D(3) in ethnic Norwegian and Tamil periodontitis patients and their periodontally healthy controls. BMC Oral Health 2019,19, 83. [CrossRef]
  186. Anbarcioglu, E.; Kirtiloglu, T.; Ozturk, A.; Kolbakir, F.; Acikgoz, G.; Colak, R. Vitamin D deficiency in patients with aggressive periodontitis. Oral Dis. 2019, 25, 242-249. [CrossRef]
  187. Ebersole, J.L.; Lambert, J.; Bush, H.; Huja, P.E.; Basu, A. Serum Nutrient Levels and Aging Effects on Periodontitis. Nutrients 2018, 10,1986. [CrossRef]
  188. Abreu, O.J.; Tatakis, D.N.; Elias-Boneta, A.R.; del Valle, L.L.; Hernandez, R.; Pousa, M.S.; Palacios, C. Low vitamin D status strongly associated with periodontitis in Puerto Rican adults. BMC Oral Health 2016,16, 89. [CrossRef]
  189. Balci Yuce, H.; Gokturk, O.; Aydemir Turkal, H.; Inanir, A.; Benli, I.; Demir, O. Assessment of local and systemic 25-hydroxy- vitamin D, RANKL, OPG, and TNF levels in patients with rheumatoid arthritis and periodontitis. J. Oral Sci. 2017, 59, 397-404. [CrossRef]
  190. Eshghi, R.; Maybodi, F.R.; Khabazian, A.; Shahhosseini, S. Association between serum levels of vitamin D and chronic periodontitis in premenopausal women in Yazd. Casp. J. Dent. Res. 2016, 5, 47-51.
  191. Joseph, R.; Nagrale, A.V.; Joseraj, M.G.; Pradeep Kumar, K.M.; Kaziyarakath, J.A.; Chandini, R. Low levels of serum Vitamin D in chronic periodontitis patients with type 2 diabetes mellitus: A hospital-based cross-sectional clinical study. J. Indian Soc. Periodontol. 2015,19, 501-506. [CrossRef] [PubMed]
  192. Heaney, R.P. Guidelines for optimizing design and analysis of clinical studies of nutrient effects. Nutr. Rev. 2014, 72, 48-54. [CrossRef]
  193. Pilz, S.; Trummer, C.; Theiler-Schwetz, V.; Grubler, M.R.; Verheyen, N.D.; Odler, B.; Karras, S.N.; Zittermann, A.; Marz, W. Critical Appraisal of Large Vitamin D Randomized Controlled Trials. Nutrients 2022,14, 303. [CrossRef]
  194. Grant, W.B.; Boucher, B.J.; al Anouti, F.; Pilz, S. Comparing the Evidence from Observational Studies and Randomized Controlled Trials for Nonskeletal Health Effects of Vitamin D. Nutrients 2022,14, 3811. [CrossRef]
  195. Manson, J.E.; Cook, N.R.; Lee, I.M.; Christen, W.; Bassuk, S.S.; Mora, S.; Gibson, H.; Gordon, D.; Copeland, T.; D'Agostino, D.; et al. Vitamin D Supplements and Prevention of Cancer and Cardiovascular Disease. N. Engl. J. Med. 2019, 380, 33-44. [CrossRef]
  196. Anderson, J.L.; May, H.T.; Horne, B.D.; Bair, T.L.; Hall, N.L.; Carlquist, J.F.; Lappe, D.L.; Muhlestein, J.B.; Intermountain Heart Collaborative (IHC) Study Group. Relation of vitamin D deficiency to cardiovascular risk factors, disease status, and incident events in a general healthcare population. Am. J. Cardiol. 2010,106, 963-968. [CrossRef] [PubMed]
  197. Sun, H.; Long, S.R.; Li, X.; Ge, H.; Liu, X.; Wang, T.; Yu, F.; Wang, Y.; Xue, Y.; Li, W. Serum vitamin D deficiency and vitamin D receptor gene polymorphism are associated with increased risk of cardiovascular disease in a Chinese rural population. Nutr. Res. 2019, 61, 13-21. [CrossRef]
  198. Zhou, A.; Selvanayagam, J.B.; Hypponen, E. Non-linear Mendelian randomization analyses support a role for vitamin D deficiency in cardiovascular disease risk. Eur. Heart J. 2022, 43,1731-1739. [CrossRef]
  199. Grant, W.B.; Bhattoa, H.P.; Boucher, B.J. Seasonal variations of U.S. mortality rates: Roles of solar ultraviolet-B doses, vitamin D, gene expression, and infections. J. Steroid Biochem. Mol. Biol. 2017,173, 5-12. [CrossRef]
  200. Grant, W.B.; Boucher, B.J. An Exploration of How Solar Radiation Affects the Seasonal Variation of Human Mortality Rates and the Seasonal Variation in Some Other Common Disorders. Nutrients 2022,14, 2519. [CrossRef]
  201. Grant, W.B. Vitamin D Acceptance Delayed by Big Pharma Following the Disinformation Playbook. Available online: http: //www.orthomolecular.org/resources/omns/v14n22.shtml (accessed on 30 March 2022).
  202. Wang, M.; Liu, M.; Wang, C.; Xiao, Y.; An, T.; Zou, M.; Cheng, G. Association between vitamin D status and asthma control: A meta-analysis of randomized trials. Respir. Med. 2019,150, 85-94. [CrossRef]
  203. Hahn, J.; Cook, N.R.; Alexander, E.K.; Friedman, S.; Walter, J.; Bubes, V.; Kotler, G.; Lee, I.M.; Manson, J.E.; Costenbader, K.H. Vitamin D and marine omega 3 fatty acid supplementation and incident autoimmune disease: VITAL randomized controlled trial. BMJ 2022, 376, e066452. [CrossRef]
  204. Keum, N.; Lee, D.H.; Greenwood, D.C.; Manson, J.E.; Giovannucci, E. Vitamin D supplementation and total cancer incidence and mortality: A meta-analysis of randomized controlled trials. Ann. Oncol. 2019, 30, 733-743. [CrossRef]
  205. Vaughan-Shaw, P.G.; Buijs, L.F.; Blackmur, J.P.; Theodoratou, E.; Zgaga, L.; Din, F.V.N.; Farrington, S.M.; Dunlop, M.G. The effect of vitamin D supplementation on survival in patients with colorectal cancer: Systematic review and meta-analysis of randomised controlled trials. Br. J. Cancer 2020,123,1705-1712. [CrossRef]
  206. Hujoel, P.P. Vitamin D and dental caries in controlled clinical trials: Systematic review and meta-analysis. Nutr. Rev. 2013, 71, 88-97. [CrossRef]
  207. Lips, P.; van Schoor, N.M. The effect of vitamin D on bone and osteoporosis. Best. Pract. Res. Clin. Endocrinol. Metab. 2011, 25, 585-591. [CrossRef]
  208. Martineau, A.R.; Jolliffe, D.A.; Hooper, R.L.; Greenberg, L.; Aloia, J.F.; Bergman, P.; Dubnov-Raz, G.; Esposito, S.; Ganmaa, D.; Ginde, A.A.; et al. Vitamin D supplementation to prevent acute respiratory tract infections: Systematic review and meta-analysis of individual participant data. BMJ 2017, 356, i6583. [CrossRef]
  209. Weller, R.B.; Wang, Y.; He, J.; Maddux, F.W.; Usvyat, L.; Zhang, H.; Feelisch, M.; Kotanko, P. Does Incident Solar Ultraviolet Radiation Lower Blood Pressure? J. Am. Heart Assoc. 2020, 9, e013837. [CrossRef]
  210. Cherrie, M.; Clemens, T.; Colandrea, C.; Feng, Z.; Webb, D.J.; Weller, R.B.; Dibben, C. Ultraviolet A radiation and COVID-19 deaths in the USA with replication studies in England and Italy. Br. J. Dermatol. 2021,185, 363-370. [CrossRef]
  211. Austin, P.C. An Introduction to Propensity Score Methods for Reducing the Effects of Confounding in Observational Studies. Multivar. Behav. Res. 2011, 46, 399-424. [CrossRef]
  212. Vargas Buonfiglio, L.G.; Vanegas Calderon, O.G.; Cano, M.; Simmering, J.E.; Polgreen, P.M.; Zabner, J.; Gerke, A.K.; Comellas, A.P. Seasonal Antimicrobial Activity of the Airway: Post-Hoc Analysis of a Randomized Placebo-Controlled Double-Blind Trial. Nutrients 2020,12, 2602. [CrossRef]
  213. Oristrell, J.; Oliva, J.C.; Casado, E.; Subirana, I.; Dominguez, D.; Toloba, A.; Balado, A.; Grau, M. Vitamin D supplementation and COVID-19 risk: A population-based, cohort study. J. Endocrinol. Investig. 2022, 45,167-179. [CrossRef]
  214. Gibbons, J.B.; Norton, E.C.; McCullough, J.S.; Meltzer, D.O.; Lavigne, J.; Fiedler, V.C.; Gibbons, R.D. Association between vitamin D supplementation and COVID-19 infection and mortality. Sci. Rep. 2022,12,19397. [CrossRef]
  215. Ghahremani, M.; Smith, E.E.; Chen, H.Y.; Creese, B.; Goodarzi, Z.; Ismail, Z. Vitamin D supplementation and incident dementia: Effects of sex, APOE, and baseline cognitive status. Alzheimers Dement. 2023,15, e12404. [CrossRef]
  216. Pittas, A.G.; Kawahara, T.; Jorde, R.; Dawson-Hughes, B.; Vickery, E.M.; Angellotti, E.; Nelson, J.; Trikalinos, T.A.; Balk, E.M. Vitamin D and Risk for Type 2 Diabetes in People With Prediabetes: A Systematic Review and Meta-analysis of Individual Participant Data From 3 Randomized Clinical Trials. Ann. Intern. Med. 2023,176, 355-363. [CrossRef]
  217. Mirhosseini, N.; Vatanparast, H.; Kimball, S.M. The Association between Serum 25(OH)D Status and Blood Pressure in Participants of a Community-Based Program Taking Vitamin D Supplements. Nutrients 2017, 9,1244. [CrossRef]
  218. Acharya, P.; Dalia, T.; Ranka, S.; Sethi, P.; Oni, O.A.; Safarova, M.S.; Parashara, D.; Gupta, K.; Barua, R.S. The Effects of Vitamin D Supplementation and 25-Hydroxyvitamin D Levels on the Risk of Myocardial Infarction and Mortality. J. Endocr. Soc. 2021, 5, bvab124. [CrossRef]
  219. McDonnell, S.L.; Baggerly, K.A.; Baggerly, C.A.; Aliano, J.L.; French, C.B.; Baggerly, L.L.; Ebeling, M.D.; Rittenberg, C.S.; Goodier, C.G.; Mateus Nino, J.F.; et al. Maternal 25(OH)D concentrations >/=40 ng/mL associated with 60% lower preterm birth risk among general obstetrical patients at an urban medical center. PLoS ONE 2017,12, e0180483. [CrossRef]
  220. Rostami, M.; Tehrani, F.R.; Simbar, M.; Bidhendi Yarandi, R.; Minooee, S.; Hollis, B.W.; Hosseinpanah, F. Effectiveness of Prenatal Vitamin D Deficiency Screening and Treatment Program: A Stratified Randomized Field Trial. J. Clin. Endocrinol. Metab. 2018,103, 2936-2948. [CrossRef]
  221. Hypponen, E.; Vimaleswaran, K.S.; Zhou, A. Genetic Determinants of 25-Hydroxyvitamin D Concentrations and Their Relevance to Public Health. Nutrients 2022,14, 4408. [CrossRef]
  222. Davies, N.M.; Holmes, M.V.; Davey Smith, G. Reading Mendelian randomisation studies: A guide, glossary, and checklist for clinicians. BMJ 2018, 362, k601. [CrossRef]
  223. Bouillon, R.; Carmeliet, G. Vitamin D insufficiency: Definition, diagnosis and management. Best Pract. Res. Clin. Endocrinol. Metab. 2018, 32, 669-684. [CrossRef]
  224. Liu, D.; Meng, X.; Tian, Q.; Cao, W.; Fan, X.; Wu, L.; Song, M.; Meng, Q.; Wang, W.; Wang, Y. Vitamin D and Multiple Health Outcomes: An Umbrella Review of Observational Studies, Randomized Controlled Trials, and Mendelian Randomization Studies. Adv. Nutr. 2021,13,1044-1062. [CrossRef]
  225. Sutherland, J.P.; Zhou, A.; Hypponen, E. Vitamin D Deficiency Increases Mortality Risk in the UK Biobank: A Nonlinear Mendelian Randomization Study. Ann. Intern. Med. 2022,175,1552-1559. [CrossRef]
  226. Mokry, L.E.; Ross, S.; Morris, J.A.; Manousaki, D.; Forgetta, V.; Richards, J.B. Genetically decreased vitamin D and risk of Alzheimer disease. Neurology 2016, 87, 2567-2574. [CrossRef]
  227. Wang, L.; Qiao, Y.; Zhang, H.; Zhang, Y.; Hua, J.; Jin, S.; Liu, G. Circulating Vitamin D Levels and Alzheimer's Disease: A Mendelian Randomization Study in the IGAP and UK Biobank. J. Alzheimers Dis. 2020, 73, 609-618. [CrossRef]
  228. Colak, Y.; Nordestgaard, B.G.; Afzal, S. Low vitamin D and risk of bacterial pneumonias: Mendelian randomisation studies in two population-based cohorts. Thorax 2021, 76, 468-478. [CrossRef]
  229. Afzal, S.; Brondum-Jacobsen, P.; Bojesen, S.E.; Nordestgaard, B.G. Vitamin D concentration, obesity, and risk of diabetes: A mendelian randomisation study. Lancet Diabetes Endocrinol. 2014, 2, 298-306. [CrossRef]
  230. Lu, L.; Bennett, D.A.; Millwood, I.Y.; Parish, S.; McCarthy, M.I.; Mahajan, A.; Lin, X.; Bragg, F.; Guo, Y.; Holmes, M.V.; et al. Association of vitamin D with risk of type 2 diabetes: A Mendelian randomisation study in European and Chinese adults. PLoS Med. 2018,15, el002566. [CrossRef]
  231. Wagner, C.L.; Hollis, B.W. The Implications of Vitamin D Status During Pregnancy on Mother and her Developing Child. Front. Endocrinol. 2018, 9, 500. [CrossRef]
  232. Merewood, A.; Mehta, S.D.; Chen, T.C.; Bauchner, H.; Holick, M.F. Association between vitamin D deficiency and primary cesarean section. J. Clin. Endocrinol. Metab. 2009, 94, 940-945. [CrossRef]
  233. Milajerdi, A.; Abbasi, F.; Mousavi, S.M.; Esmaillzadeh, A. Maternal vitamin D status and risk of gestational diabetes mellitus: A systematic review and meta-analysis of prospective cohort studies. Clin. Nutr. 2021, 40, 2576-2586. [CrossRef] [PubMed]
  234. Yuan, Y.; Tai, W.; Xu, P.; Fu, Z.; Wang, X.; Long, W.; Guo, X.; Ji, C.; Zhang, L.; Zhang, Y.; et al. Association of maternal serum 25-hydroxyvitamin D concentrations with risk of preeclampsia: A nested case-control study and meta-analysis. J. Matern. Fetal Neonatal Med. 2021, 34,1576-1585. [CrossRef] [PubMed]
  235. Souberbielle, J.C.; Body, J.J.; Lappe, J.M.; Plebani, M.; Shoenfeld, Y.; Wang, T.J.; Bischoff-Ferrari, H.A.; Cavalier, E.; Ebeling, P.R.; Fardellone, P.; et al. Vitamin D and musculoskeletal health, cardiovascular disease, autoimmunity and cancer: Recommendations for clinical practice. Autoimmun. Rev. 2010, 9, 709-715. [CrossRef]
  236. Ross, A.C.; Manson, J.E.; Abrams, S.A.; Aloia, J.F.; Brannon, P.M.; Clinton, S.K.; Durazo-Arvizu, R.A.; Gallagher, J.C.; Gallo, R.L.; Jones, G.; et al. The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: What clinicians need to know. J. Clin. Endocrinol. Metab. 2011, 96, 53-58. [CrossRef] [PubMed]
  237. Holick, M.F.; Binkley, N.C.; Bischoff-Ferrari, H.A.; Gordon, C.M.; Hanley, D.A.; Heaney, R.P.; Murad, M.H.; Weaver, C.M.; Endocrine, S. Evaluation, treatment, and prevention of vitamin D deficiency: An Endocrine Society clinical practice guideline. J. Clin. Endocrinol. Metab. 2011, 96,1911-1930. [CrossRef] [PubMed]
  238. Pludowski, P.; Karczmarewicz, E.; Bayer, M.; Carter, G.; Chlebna-Sokol, D.; Czech-Kowalska, J.; Debski, R.; Decsi, T.; Dobrzanska, A.; Franek, E.; et al. Practical guidelines for the supplementation of vitamin D and the treatment of deficits in Central Europe— Recommended vitamin D intakes in the general population and groups at risk of vitamin D deficiency. Endokrynol. Pol. 2013, 64, 319-327. [CrossRef] [PubMed]
  239. Bouillon, R. Comparative analysis of nutritional guidelines for vitamin D. Nat. Rev. Endocrinol. 2017,13, 466-479. [CrossRef]
  240. Pludowski, P.; Holick, M.F.; Grant, W.B.; Konstantynowicz, J.; Mascarenhas, M.R.; Haq, A.; Povoroznyuk, V.; Balatska, N.; Barbosa, A.P.; Karonova, T.; et al. Vitamin D supplementation guidelines. J. Steroid Biochem. Mol. Biol. 2018,175,125-135. [CrossRef]
  241. Haq, A.; Wimalawansa, S.J.; Pludowski, P.; Anouti, F.A. Clinical practice guidelines for vitamin D in the United Arab Emirates. J. Steroid Biochem. Mol. Biol. 2018,175, 4-11. [CrossRef]
  242. Lips, P.; Cashman, K.D.; Lamberg-Allardt, C.; Bischoff-Ferrari, H.A.; Obermayer-Pietsch, B.; Bianchi, M.L.; Stepan, J.; El-Hajj Fuleihan, G.; Bouillon, R. Current vitamin D status in European and Middle East countries and strategies to prevent vitamin D deficiency: A position statement of the European Calcified Tissue Society. Eur. J. Endocrinol. 2019,180, P23-P54. [CrossRef]
  243. Pludowski, P.; Takacs, I.; Boyanov, M.; Belaya, Z.; Diaconu, C.C.; Mokhort, T.; Zherdova, N.; Rasa, I.; Payer, J.; Pilz, S. Clinical Practice in the Prevention, Diagnosis and Treatment of Vitamin D Deficiency: A Central and Eastern European Expert Consensus Statement. Nutrients 2022,14,1483. [CrossRef]
  244. Pludowski, P.; Kos-Kudla, B.; Walczak, M.; Fal, A.; Zozulinska-Ziolkiewicz, D.; Sieroszewski, P.; Peregud-Pogorzelski, J.; Lauterbach, R.; Targowski, T.; Lewinski, A.; et al. Guidelines for Preventing and Treating Vitamin D Deficiency: A 2023 Update in Poland. Nutrients 2023,15, 695. [CrossRef]
  245. Grant, W.B.; al Anouti, F.; Boucher, B.J.; Fakhoury, H.M.; Moukayed, M.; Pilz, S.; Al-Daghri, N.M. Evidence That Increasing Serum 25(OH)D Concentrations to 30 ng/mL in the Kingdom of Saudi Arabia and the United Arab Emirates Could Greatly Improve Health Outcomes. Biomdeicines 2023,11, 994. [CrossRef] [PubMed]
  246. Drincic, A.T.; Armas, L.A.; van Diest, E.E.; Heaney, R.P. Volumetric dilution, rather than sequestration best explains the low vitamin D status of obesity. Obesity 2012,20,1444-1448. [CrossRef] [PubMed]
  247. Furman, D.; Campisi, J.; Verdin, E.; Carrera-Bastos, P.; Targ, S.; Franceschi, C.; Ferrucci, L.; Gilroy, D.W.; Fasano, A.; Miller, G.W.; et al. Chronic inflammation in the etiology of disease across the life span. Nat. Med. 2019, 25,1822-1832. [CrossRef] [PubMed]
  248. Roizen, J.D.; Long, C.; Casella, A.; O'Lear, L.; Caplan, I.; Lai, M.; Sasson, I.; Singh, R.; Makowski, A.J.; Simmons, R.; et al. Obesity Decreases Hepatic 25-Hydroxylase Activity Causing Low Serum 25-Hydroxyvitamin D. J. Bone Miner. Res. 2019, 34,1068-1073. [CrossRef]
  249. Palaniswamy, S.; Gill, D.; de Silva, N.M.; Lowry, E.; Jokelainen, J.; Karhu, T.; Mutt, S.J.; Dehghan, A.; Sliz, E.; Chasman, D.I.; et al. Could vitamin D reduce obesity-associated inflammation? Observational and Mendelian randomization study. Am. J. Clin. Nutr. 2020, 111, 1036-1047. [CrossRef]
  250. Ogden, C.L.; Fakhouri, T.H.; Carroll, M.D.; Hales, C.M.; Fryar, C.D.; Li, X.; Freedman, D.S. Prevalence of Obesity Among Adults, by Household Income and Education—United States, 2011-2014. MMWR Morb. Mortal. Wkly. Rep. 2017, 66,1369-1373. [CrossRef]
  251. Wang, Y.; Beydoun, M.A.; Min, J.; Xue, H.; Kaminsky, L.A.; Cheskin, L.J. Has the prevalence of overweight, obesity and central obesity levelled off in the United States? Trends, patterns, disparities, and future projections for the obesity epidemic. Int. J. Epidemiol. 2020, 49, 810-823. [CrossRef]
  252. Bray, G.A.; Heisel, W.E.; Afshin, A.; Jensen, M.D.; Dietz, W.H.; Long, M.; Kushner, R.F.; Daniels, S.R.; Wadden, T.A.; Tsai, A.G.; et al. The Science of Obesity Management: An Endocrine Society Scientific Statement. Endocr. Rev. 2018, 39, 79-132. [CrossRef]
  253. Cornelius, M.E.; Loretan, C.G.; Jamal, A.; Davis Lynn, B.C.; Mayer, M.; Alcantara, I.C.; Neff, L. Tobacco Product Use Among Adults—United States, 2021. MMWRMorb. Mortal. Wkly. Rep. 2023, 72, 475-483. [CrossRef]
  254. Stoody, E.E. Dietary Guidelines for Americans, 2020-2025; U.S. Dept of Agriculrure: WA, DC, USA, 2020; p. 149.
  255. Evert, A.B.; Dennison, M.; Gardner, C.D.; Garvey, W.T.; Lau, K.H.K.; MacLeod, J.; Mitri, J.; Pereira, R.F.; Rawlings, K.; Robinson, S.; et al. Nutrition Therapy for Adults With Diabetes or Prediabetes: A Consensus Report. Diabetes Care 2019, 42, 731-754. [CrossRef]
  256. Fassler, J. Inside Big Beef's Climate Messaging Machine: Confuse, Defend and Downplay. Available online: https://www.theguardian.com/environment/2023/may/03/beef-industry-public-relations-messaging-machine?CMP=share_btn_tw (ac­cessed on 20 May 2023).

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